Ok, this has been a superbusy week so this is all the game preview I can write in 15 minutes. It'll be like a preview typed out on an iPhone, but probably worse than that.
Offense
Bell. Bell. Bell. Pass. If that pass goes well, then it should turn more into Bell. Bell. Pass. If that goes well then the playcalling should move to a Bell. Pass. Bell. Pass. Pass. Bell type model. And who knows, this is MSU-ND, you could very well see an actual Bell Pass. The ND game in 2011 is where Roushar was going to grandly unveil the Unbalanced Line he had been plainly working on all offseason, but MSU got behind early and running is not useful when you're down two touchdowns on the scoreboard but behind seven TD's in your heart. MSU will look to set up the pass as early as they can get away with because ND's secondary is wet-behind-the-ears, but their front seven is probably the best MSU will see this year(with apologies to Urbz and OSU).
Defense
Holy Defense! Pat Narduzzi ripped his defense for "not allowing an offensive touchdown" this year. He's like that fan back during the Minnesota game in 2010 who bitched at the MSU defense for having allowed zero points to that point in the game. That guy was a clown shoe. Pat Narduzzi is not a clown shoe. MSU played some pretty vanilla defense against CMU but didn't get oodles of push on CMU's offensive line. So, who the hell knows. This is the frustrating part of the college football season, you don't know what playbook doesn't exist and what playbook is just being kept secret for uncovering at a key moment of making Brian Kelly angry.
Obligatory Little Giants Drop
This play is overdone, but holy crap I can't remember a longer eternity that lived inside my head for just the two seconds the ball was in the air.
Is Brian Kelly an angry oompa-loompa?

No man, he's a huggable care bear.
Prediction
The thing about MSU-ND games is that they are close and the home team usually wins. The strengths and weaknesses of these teams cancel each other out well. MSU's run game is strong, ND's run defense is strong. MSU's pass game is not as strong(although ranked first in the Big Ten!!!!) and ND's pass defense is not as strong. In the end though, I don't think the defense has really had to work at it yet to hold their opponents scoreless and that's why I think MSU wins this game.
Obligatory Score Pick
MSU 20 Notre Dame 17